Diamondbacks vs Padres: Game 1 prediction, odds, injuries, and picks - June 13, 2025

NL West hopefuls, the Arizona Diamondbacks and San Diego Padres, are set to lock horns on Friday for the first of three games at Chase Field over the weekend. So far, Arizona is exactly .500 and fourth in the standings with a 34-34 record, while San Diego is one place better off in third at 38-29.

Let's take a look at the odds for Friday's series opener and how the action might play out on the field.

Diamondbacks vs Padres prediction

Taking the mound for the hosts is Ryne Nelson, who is enjoying a decent season so far, with a 2-2 record, a 4.60 ERA and 38 total strikeouts.

Ryne Nelson in action against the Cincinnati Reds - Game Two - Source: Getty

Offensively, Eugenio Suarez, Ketel Marte, Corbin Carroll and Josh Naylor are enjoying strong seasons for Arizona.

For the visitors, it is relief pitcher turned starter Stephen Kolek who makes his latest start. On paper, Kolek has fared slightly better than his counterpart, boasting a 3-1 record, along with a 3.00 ERA and 29 total strikeouts.

At the plate, Manny Machado, Jackson Merrill, Fernando Tatis Jr. and Gavin Sheets have been doing much of the heavy lifting for San Diego.

Though the pitching matchup leans slightly in the visitors' favor, the D-backs are a force to be reckoned with at home and should be able to find a way to secure a hard-fought win here.

Prediction: Arizona Diamondbacks 5, San Diego Padres 4

Odds

Money Line: Arizona Diamondbacks -137, San Diego Padres +112

Run Line: Arizona -1.5 (+139), Padres +1.5 (-172)

Total Runs: Over 8.5 (-164), Under 8.5 (+133)

Injury report

Diamondbacks injuries

Kendall Graveman: 15-day IL (Hip)
Christian Montes De Oca: 15-day IL (Elbow)
Justin Martinez: 15-day IL (Elbow)
Blake Walston: 60-day IL (Elbow)
Corbin Burnes: 60-day IL (Elbow)
A.J. Puk: 60-day IL (Elbow)
Cristian Mena: 60-day IL (Shoulder)
Jordan Montgomery: 60-day IL (Elbow)

San Diego injuries

Jason Heyward: 10-day IL (Oblique)
Logan Gillaspie: 15-day IL (Oblique )
Yu Darvish: 15-day IL (Elbow)
Michael King: 15-day IL (Shoulder)
Jhony Brito: 60-day IL (Forearm)
Bryan Hoeing: 60-day IL (Shoulder)
Joe Musgrove: 60-day IL (Elbow)

Expert's picks

Coming into this game after sweeping the Seattle Mariners, the D-backs should find a way to carry their momentum forward and secure another important win to take them above .500.

Money Line: Arizona Diamondbacks -137

Run Line: Padres +1.5 (-172)

Total Runs: Over 8.5 (-164)