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Dodgers vs Padres: Game 2 prediction, odds, injuries and picks - June 10, 2025

The Los Angeles Dodgers and San Diego Padres battle it out once again on Tuesday, taking each other on for the second of three games at Petco Park.

Having won the series opener, the visitors, who are leading the NL West, improved their record for the season to 40-27. The hosts, meanwhile, slipped to third and are 37-28 after last night's loss.

Let's take a look at the odds for Tuesday's matchup and how the action might pan out on the diamond.

Dodgers vs Padres prediction

The Dodgers have not yet confirmed a starting pitcher for Tuesday's game. Offensively, the visitors boast one of the most potent hitting lineups in all of baseball, featuring the likes of Shohei Ohtani, Freddie Freeman, Mookie Betts and Will Smith.

Miami Marlins v Los Angeles Dodgers - Source: Getty
Miami Marlins v Los Angeles Dodgers - Source: Getty

San Diego, on the other hand, is sending Dylan Cease to the mound. So far, Cease has enjoyed a decent season, pitching with a 1-5 record, along with a 4.72 ERA and 85 total strikeouts.

At the plate, Fernando Tatis Jr., Manny Machado, Jackson Merrill and Gavin Sheets have been doing much of the heavy lifting for the Padres.

Having suffered a heartbreaking loss after extra innings on Monday, the hosts should be able to hit back in this one and set up a riveting series finale.

Prediction: Los Angeles Dodgers 4, San Diego Padres 5

Odds

Money Line: Los Angeles Dodgers -104, San Diego Padres -112

Run Line: Dodgers +1.5 (+222), San Diego -1.5 (+160)

Total Runs: Over 8.5 (-105), Under 8.5 (-125)

Injury report

Dodgers injuries:

Luís Garcia: 15-day IL (Adductor)

Roki Sasaki: 15-day IL (Shoulder)

Tony Gonsolin: 15-day IL (Elbow)

Gavin Stone: 60-day IL (Shoulder)

River Ryan: 60-day IL (Elbow)

Brusdar Graterol: 60-day IL (Shoulder)

Edgardo Henriquez: 60-day IL (Foot)

Emmet Sheehan: 60-day IL (Elbow)

Blake Treinen: 60-day IL (Forearm)

Tyler Glasnow: 60-day IL (Shoulder)

Kyle Hurt: 60-day IL (Elbow)

Michael Grove: 60-day IL (Shoulder)

Evan Phillips: 60-day IL (Forearm)

Blake Snell: 60-day IL (Shoulder)

San Diego injuries:

Jason Heyward: 10-day IL (Oblique)

Logan Gillaspie: 15-day IL (Oblique )

Yu Darvish: 15-day IL (Elbow)

Michael King: 15-day IL (Shoulder)

Jhony Brito: 60-day IL (Forearm)

Bryan Hoeing: 60-day IL (Shoulder)

Joe Musgrove: 60-day IL (Elbow)

Expert picks

Like Monday's game, this game has all the makings of quite a closely-contested affair. Having ended up on the wrong end of a one-run ballgame in the opener, the hosts should be able to find a way to inflict a similar defeat on their arch-rivals on Tuesday.

Money Line: San Diego Padres -112

Run Line: Dodgers +1.5 (-222)

Total Runs: Over 8.5 (-105)

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