Padres vs Pirates: Game 3 prediction, odds, injuries, and picks - June 1, 2025

The Pittsburgh Pirates were able to get their first win against the San Diego Padres in five attempts this season with a shutout 5-0 victory on Saturday thanks to a 2-hit 6.1 innings outing by ace Bailey Falter. The road team had dropped the first game to San Diego in a close 3-2 loss.

The Pirates are trying to get back in form, and a win on Sunday would be their 8th win in 12 games. They are last in the NL Central with a 22-37 record. The gap between the Padres and the Los Angeles Dodgers in the NL West standings has grown to 3.0 games. They are 5-5 in their last ten games, getting outscored by 21 runs.

Padres vs. Pirates Game 3: Betting Odds & Weather

Date & Time: Sunday, June 1, 2025 at 5:10 p.m. ET

Money Line: Padres -229

Over/Under: Over 7.5 runs

Weather: Partly Cloudy, 72 degrees F, Wind 10 mph L-R, 39% chance of precipitation

Padres vs. Pirates Game 3: Injuries & Lineups

Injuries

Padres

• Jason Heyward: 10 Day IL (Oblique),
• Mason McCoy: 10 Day IL (Finger),
• Logan Gillaspie: 15 Day IL (Oblique ),
• Yu Darvish: 15 Day IL (Elbow),
• Michael King: 15 Day IL (Shoulder),
• Jhony Brito: 60 Day IL (Forearm),
• Bryan Hoeing: 60 Day IL (Shoulder),
• Matt Waldron: 60 Day IL (Oblique),
• Joe Musgrove: 60 Day IL (Elbow)

Pirates

• Colin Holderman: 15 Day IL (Thumb),
• Tim Mayza: 60 Day IL (Shoulder),
• Justin Lawrence: 60 Day IL (Elbow),
• Johan Oviedo: 60 Day IL (Elbow),
• Nick Gonzales: 60 Day IL (Ankle),
• Dauri Moreta: 60 Day IL (Elbow),
• Jared Jones: 60 Day IL (Elbow),
• Enmanuel Valdez: 60 Day IL (Shoulder),
• Joey Bart: 7 Day IL (Concussion)

Expected Lineups

Padres

1. RF F. Tatis [R]
2. 1B Luis Arraez [L]
3. DH M. Machado [R]
4. CF J. Merrill [L]
5. SS X. Bogaerts [R]
6. 2B J. Cronenworth [L]
7. 3B J. Iglesias [R]
8. LF B. Lockridge [R]
9. C M. Maldonado [R]

Pirates

1. CF Oneil Cruz [L]
2. DH A. McCutchen [R]
3. RF B. Reynolds [S]
4. LF A. Canario [R]
5. 1B S. Horwitz [L]
6. C Henry Davis [R]
7. 2B Adam Frazier [L]
8. 3B K. Hayes [R]
9. SS I. Kiner-Falefa [R]

Padres vs. Pirates Game 3: Prediction and Picks

The starting pitching matchup is expected to be a close-fought contest. Padres' Randy Vasquez (3-4, 3.58 ERA, 1.39 WHIP, 32 SOs) and Pirates' Andrew Heaney (3-4, 3.41 ERA, 1.22 WHIP, 44 SOs) have near identical numbers and both will be making their 12th starts of the season.

The Pirates offense is better off with a .280 average in their last ten games, compared to Padres' .200 team average. Bryan Reynolds has hit 15-for-39 with 12 RBIs during that stretch for Pittsburgh.

For San Diego, Gavin Sheets has been a big find, having hit 11 RBIs, including 5 home runs, in his last ten games. Oneil Cruz and Fernando Tatis Jr. lead their respective teams in home runs hit.

Prediction: Padres 4, Pirates 3

Picks: Padres -229

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