Rays vs Red Sox: Game 2 prediction, odds, injuries, and picks - June 10, 2025

The Red Sox are looking to avenge their extra-innings loss to the Rays in the opening match of the series. After being down in multiple stages of the game, Boston forced extras through Kristian Campbell's RBI-single in the bottom of the ninth.

However, the visitors still prevailed after Jake Magnum's two-run go-ahead single in the 11th gave the Rays the 10-8 victory.

Game 2 should see the Sox deploy Lucas Giolito to begin the proceedings opposite the Rays' Ryan Pepiot. Unlike Giolito's 6.42 ERA, Pepiot has maintained a respectable 3.20 ERA with 64 punch-outs this season.

Rays vs. Red Sox recent form and records

Boston is caught in a peculiar situation as, along with the Rangers, they're the only two teams in MLB that own a positive run differential despite a losing record. The inconsistency has led Boston to a 32-36 record — 4.5 games behind the AL wild card spots.

The Rays, meanwhile, are steadily and quietly climbing up the AL East table. Tampa Bay holds a 36-30 record and has now won seven of its last 10 fixtures.

Rays vs. Red Sox odds

Money Line: TB (-101), BOS (-108)

Run Spread: TB -1.5 (+143), BOS +1.5 (-175)

Total Runs: O 9.5 (+102), U 9.5 (-123)

Rays vs. Red Sox injuries

TB injuries

Shane McClanahan (SP): 60-day IL (triceps)
Ha-Seong Kim (SS): 60-day IL (shoulder)
Hunter Bigge (RP): 15-day IL (lat)
Jonny DeLuca (CF): 60-day IL (shoulder)
Nate Lavender (RP): 60-day IL (elbow)
Alex Faedo (RP): 60-day IL (shoulder)
Richie Palacios (LF): 10-day IL (knee)

BOS injuries

Kutter Crawford (SP): 60-day IL (knee)
Tanner Houck (SP): 15-day IL (elbow)
Triston Casas (1B): 60-day IL (knee)
Alex Bregman (3B): 10-day IL (quad)
Patrick Sandoval (SP): 60-day IL (elbow)
Masataka Yoshida (LF): 60-day IL (shoulder)
Justin Slaten (RP): 15-day IL (elbow)
Wilyer Abreu (RF): 10-day IL (oblique)

Rays vs. Red Sox projected lineup

TB projected lineup

Josh Lowe (RF)
Brandon Lowe (2B)
Yandy Diaz (DH)
Jonathan Aranda (1B)
Junior Caminero (3B)
Jake Magnum (LF)
Kameron Misner (CF)
Jose Caballero (SS)
Danny Jansen (C)
Ryan Pepiot (SP, 3-5 | 3.20 ERA | 64 K)

BOS projected lineup

Jarren Duran (LF)
Rafael Devers (DH)
Abraham Toro (1B)
Trevor Story (SS)
Roman Anthony (RF)
Carlos Narvaez (C)
Marcelo Mayer (3B)
Kristian Campbell (2B)
Ceddanne Rafaela (CF)
Lucas Giolito (SP, 1-1 | 3.42 ERA | 27 K)

Rays vs. Red Sox picks and game prediction

Given the disparity in form between the starting pitchers of the two squads, the Rays have a very slight advantage against the Sox. However, it should still be a nip-and-tuck affair as proven by Boston in Game 1, wherein they made multiple comebacks before ultimately falling short in extras.

Run Line: TB -1.5 (+143)

Total Runs: O 9.5 (+102)

Prediction: TB wins, 7-5