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Red Sox vs. Orioles: Game 4 prediction, odds, injuries and picks - May 25, 2025

The Boston Red Sox seek retribution for their surprising 2-1 loss at the hands of the Baltimore Orioles in Game 3 of their four-game series. After overwhelming the visitors in Game 1 and winning the first of the double-header yesterday, Boston was narrowly edged out by Baltimore in a game wherein the runs were scored in the dying embers of the contest.

Ryan O'Hearn's RBI-single and Dylan Carlson's RBI-double were enough to keep Boston at bay, with the latter only being able to score through Abraham Toro's solo shot in the ninth.

Red Sox vs. Orioles recent form and records

Boston continues to be a middle-of-the-pack team both in terms of its statistics and in terms of its win-loss record. They possess a 27-27 record that is good for the second-best in the AL East.

The Orioles, meanwhile, have left much to be desired this year. Outside of the struggling Rockies, the team has posted the second-worst run differential at -99. With a 17-34 record, they are at the bottom of the AL East, and if not for the White Sox, they would be at the bottom of the American League standings as well.

Players to watch

Starting pitchers

BOS: Walker Buehler (4-1, 4.00 ERA, 33 K), BAL: Dean Kremer (3-5, 5.50 ERA, 40 K)

Boston Red Sox

Two-time World Series champion Walker Buehler has had a respectable start for his new club. Buehler has posted a 4-1 record with a 4.00 ERA and 33 strikeouts across seven games.

Unlike in previous years, Buehler has strayed away from relying on his fastball and has increased his use of sweepers and changeups. The diversity of his pitches has placed him within the 94th percentile in average exit velocity and 93rd percentile in hard-hit percentage, meaning that he rarely lets hitters go yard with his pitches.

Must-Watch Hitters

Baltimore Orioles

Although the pitching staff has been disastrous, the Orioles offense has been the streak of light in their dark season. One such case is Ryan O'Hearn, who has tallied seven home runs and 17 RBI. He's also batting at a decent .315/.405/.500 with an OPS of .905.

Red Sox vs. Orioles baseball betting odds

Sunday, 5/25Money LineRun LineTotal Runs
BOS-135-1.5, +144O 9.5,  -105
BAL+122+1.5, -177U 9.5, -115

Red Sox vs. Orioles expert picks and game prediction

The Red Sox are quite favored in the series-closer at home. Even though they've had their own share of struggles this year, it isn't enough to simply be overwhelmed by a flailing Orioles team.

Run Line: -1.5, +144

Total Runs: O 9.5, -105

Prediction: BOS wins, 8-3

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