Red Sox vs Yankees: Game 1 prediction, odds, injuries, and picks - June 13, 2025

Just a week removed from their exciting clash in the Bronx, the mortal rivals Yankees and Red Sox are set to add another chapter to their storied history on Friday. This time, however, the latter would have the home-field advantage as the series shifts to Boston.

The Sox came away with the 2-1 series victory the last time around as they exploded for 27 runs across three games. Yankee starter Ryan Yarbrough has his work cut out for him as he's scheduled to face Boston ace Garrett Crochet.

Red Sox vs. Yankees recent form and records

Boston is coming off a series victory against the Rays that improved the former's record to 34-36. Although the Sox posted a 19-17 record at home, the squad still sits in fourth place in the AL East.

On the contrary, things are on the up-and-up for the defending AL pennant winners. The Bombers lead the division with a 42-25 record and are coming off a sweep of the Royals. Aaron Boone's men have also built an impressive 21-13 record on the road.

Red Sox vs. Yankees odds

Money Line: BOS (-143), NYY (+129)

Run Spread: BOS -1.5 (+141), NYY +1.5 (-172)

Total Runs: O 8.5 (-112), U 8.5 (-110)

Red Sox vs. Yankees injuries

BOS injury report

Kutter Crawford (SP): 60-day IL (knee)
Tanner Houck (SP): 15-day IL (elbow)
Triston Casas (1B): 60-day IL (knee)
Alex Bregman (3B): 10-day IL (quad)
Patrick Sandoval (SP): 60-day IL (elbow)
Masataka Yoshida (LF): 60-day IL (shoulder)
Justin Slaten (RP): 15-day IL (elbow)
Wilyer Abreu (RF): 10-day IL (oblique)
Nick Burdi (RP): 15-day IL (foot)
Liam Hendriks (RP): 15-day IL (hip)
Chris Murphy (RP): 60-day IL (elbow)

NYY injury report

Luke Weaver (RP): Out (hamstring)
Gerrit Cole (SP): 60-day IL (elbow)
Oswaldo Cabrera (3B): 10-day IL (ankle)
Giancarlo Stanton (DH): 60-day IL (elbows)
Marcus Stroman (SP): 15-day IL (knee)
J.T. Brubaker (SP): 60-day IL (ribs)
Luis Gil (SP): 60-day IL (lat)
Jake Cousins (RP): 60-day IL (forearm)

Red Sox vs. Yankees projected lineup

BOS projected lineup

Jarren Duran (LF)
Rafael Devers (DH)
Robert Refsnyder (RF)
Carlos Narvaez (C)
Romy Gonzalez (1B)
Abraham Toro (3B)
Trevor Story (SS)
Roman Anthony (CF)
Kristian Campbell (2B)
Garrett Crochet (SP, 6-4 | 2.35 ERA | 110 K)

NYY projected lineup

Paul Goldschmidt (1B)
Trent Grisham (CF)
Aaron Judge (DH)
Cody Bellinger (RF)
Anthony Volpe (SS)
Jazz Chisholm Jr. (3B)
Jasson Dominguez (LF)
D.J. LeMahieu (2B)
Austin Wells (C)
Ryan Yarbrough (SP, 3-1 | 4.17 ERA | 43 K)

Red Sox vs. Yankees and game prediction

With home-field advantage and ace Garrett Crochet starting, the Red Sox are favored in the opening matchup of the series. Nevertheless, expect fireworks from the sworn rivals.

Run Line: BOS -1.5 (+141)

Total Runs: O 8.5 (-112)

Prediction: BOS wins, 8-6