Reds vs Guardians: Game 2 prediction, odds, injuries and picks - June 10, 2025

The Cincinnati Reds look to continue the momentum in the Ohio Cup against the Cleveland Guardians after a comfortable win in the opening fixture. The Reds came away with a 7-4 victory on the road as they improved their record above .500.

Jake Fraley played a starring role for the visitors after going 3-for-4 with a solo home run, two RBI, two runs scored and a stolen base.

Game 2 should see a better input on the mound for Cincinnati with Andrew Abbott starting. Abbott holds a 5-1 record with a 2.18 ERA.

Reds vs. Guardians recent form and records

The Redlegs have yet to lose to the Guardians this year, with a 4-0 record versus their Ohio counterparts. Cincinnati has posted a 34-33 record and is on a four-game winning streak. However, despite all of this, they are still just in the fourth spot in their division.

The Guardians, meanwhile, are searching for form as they've fallen to the third spot in the AL Central with a 34-31 record. The team has only won four of its last six games and possesses a -22 run differential.

Reds vs. Guardians odds

Money Line: CIN (-101), CLE (-108)

Run Spread: CIN -1.5 (+157), CLE +1.5 (-194)

Total Runs: O 8.5 (-104), U 8.5 (-114)

Reds vs. Guardians injuries

CIN injury report

Noelvi Marte (3B): 10-day IL (oblique)
Austin Hays (LF): 10-day IL (foot)
Hunter Greene (SP): 15-day IL (back, groin)
Rhett Lowder (SP): 60-day IL (forearm/oblique)
Jeimer Candelario (3B): 10-day IL (back)
Carson Spiers (SP): 60-day IL (shoulder)
Tyler Callihan (LF): 60-day IL (forearm)
Brandon Williamson (SP): 60-day IL (elbow)

CLE injury report

Austin Hedges (C): 7-day IL (concussion)
Shane Bieber (SP): 60-day IL (elbow)
Lane Thomas (CF): 10-day IL (foot)
Will Brennan (RF): 10-day IL (forearm)
Ben Lively (SP): 60-day IL (elbow)
Paul Sewald (RP): 15-day IL (shoulder)
Sam Hentges (RP): 60-day IL (shoulder)
Trevor Stephan (RP): 60-day IL (elbow)
Andrew Walters (RP): 60-day IL (lat)

Reds vs. Guardians projected lineup

CIN projected lineup

T.J. Friedl (CF)
Gavin Lux (DH)
Elly De La Cruz (SS)
Christian Encarnacion-Strand (3B)
Will Benson (LF)
Tyler Stephenson (C)
Spencer Steer (1B)
Jake Fraley (RF)
Matt McLain (2B)
Andrew Abbott (SP, 5-1 | 2.18 ERA | 59 K)

CLE projected lineup

Steven Kwan (LF)
Lane Thomas (CF)
Jose Ramirez (3B)
David Fry (DH)
Carlos Santana (1B)
Gabriel Arias (SS)
Johnathan Rodriguez (RF)
Bo Naylor (C)
Angel Martinez (2B)
Slade Cecconi (SP, 1-2 | 4.87 ERA | 20 K)

Reds vs. Guardians picks and game prediction

The Reds are very slightly favored by the bookmakers given their recent success against the Guardians. In addition, starter Andrew Abbott has played a starring role on the bump this year for Cincinnati. Expect fireworks in Game 2 between the Ohio squads.

Run Line: CIN -1.5 (+157)

Total Runs: O 8.5 (-104)

Prediction: CIN wins, 8-3