Nebraska vs. Purdue prediction and betting tips - September 28 | College Football Week 5

The Nebraska Cornhuskers will travel to West Lafayette, Indiana, to take on the Purdue Boilermakers in a Week 5 Big Ten showdown.

The Cornhuskers suffered their first loss of the season in Week 4 after a 3-0 start. The No. 19 Illinois Fighting Illini bested Nebraska 31-24 in overtime in Lincoln. Nebraska fell out of the AP Top 25 with the loss but will look to bounce back in Week 5.

Purdue couldn't get an ideal start after winning their season opener 49-0 versus the Indiana State Sycamores. The Boilermakers are on a two-game skid, getting blown out by Notre Dame at home in a 66-7 loss before their Week 3 defeat at the hands of the Oregon State Beavers.

With these Big Ten rivals set to square off on Saturday, here are our official game predictions and betting tips.

Nebraska vs. Purdue: Prediction

Nebraska will go on the road for the first time this season, making the spread for this game closer than if Purdue were traveling to Lincoln. Despite the home-field advantage, the Boilermakers haven't played up to the caliber of their opponents, a trend likely to continue in Week 5.

The Cornhuskers will take the win over Purdue this week. With a talented offense and one of the top defensive units in the Big Ten, we'll take Nebraska to smother Purdue and cover their 10-point spread.

Nebraska vs. Purdue: Betting Tips

Tip 1: Nebraska Cornhuskers -10 (-110)

Tip 2: Isaiah Neyor Anytime TD (+130)

Tip 3: Devin Mockobee Over 55.5 Rushing Yards (-118)

Nebraska vs. Purdue: Head-to-Head

The Boilermakers and Cornhuskers have squared off just 12 times in their 66-year history, with Saturday marking the 13th matchup between the two schools.

This series has been split down the middle, with Nebraska and Purdue each winning six games each. Following their first matchup on September 27, 1958, Purdue and Indiana didn't see each other again until the 2013 season. Nebraska won last year, defeating Purdue 31-14.

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