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Notre Dame vs. Purdue Prediction & Betting Tips - September 14 | College Football Week 3

The No. 18 Notre Dame Fighting Irish will travel to Ross-Ade Stadium in West Lafayette, Indiana, to take on the Purdue Boilermakers in Week 3. Notre Dame is coming off a historic 16-14 loss to Northern Illinois in Week 2.

Purdue opened its season with an impressive 49-0 win over the Indiana State Sycamores on Aug. 31. The Fighting Irish will look to bounce back in Week 3, while the Boilermakers will try to put the 18th-ranked team on upset alert for the second straight week.

With these teams set to square off on Saturday, here are the game's predictions and betting tips.

Notre Dame vs. Purdue: Prediction

This game is a tough one to analyze for several reasons. For one, Notre Dame looked outmatched against a lower-tier opponent in NIU at home. Highly touted transfer Riley Leonard looked uncomfortable throughout the game, and the Fighting Irish's offense struggled.

While one would imagine Leonard and Notre Dame will be fueled by this upset for a Week 3 bounce-back performance, Purdue has built their recent legacy on upset wins and will look to add another this weekend. Given most sportsbooks' relative lack of faith in the Fighting Irish, giving them just 10 points over Purdue (per ESPN Bet), we're going to take the Boilermakers to kick Notre Dame while they're down.

Notre Dame vs. Purdue: Betting Tips

Tip 1: Purdue Boilermakers +10 (-115)

Tip 2: Purdue Total Points Over 16.5 (-135)

Tip 3: Devin Mockobee Total Rushing Yards Over 49.5 (-118)

Notre Dame vs. Purdue: Head-to-Head

The lengthy rivalry of Notre Dame versus Purdue will see its 88th installment on Saturday, dating back to 1896. The Fighting Irish lead the series 59-26-2. In their latest matchup, the Fighting Irish walked away with a 27-13 win on Sept. 18, 2021.

Purdue's last win came back in 2007, with the Boilermakers taking down Notre Dame 33-19 in West Lafayette.

Where to watch Notre Dame vs. Purdue

Notre Dame vs Purdue will be available on NBC and CBS. The game will stream on YouTube TV, Fubo, Paramount+, Sling TV, ESPN+, Peacock and Hulu+.

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