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SMU vs. Louisville: SI score prediction for College Football Week 6 ft. odds & picks

Week 6 of the Atlantic Coast Conference schedule has an intriguing game at L&N Federal Credit Union Stadium as the SMU Mustangs take on the No. 22 Louisville Cardinals. Both teams are trying to get a share of first place in the conference as they believe they can win the conference championship and make the College Football Playoff this year.

The Mustangs (4-1, 1-0 ACC) are on a two-game winning streak after Saturday's 42-16 home victory over the Florida State Seminoles. The Cardinals, meanwhile, (3-1, 1-0) are looking to recover after losing on the road against the Notre Dame Fighting Irish 31-24 on Saturday.

SMU vs. Louisville score prediction Week 6

The Mustangs and Cardinals are both playing at a great level so far this season which should lead to an intriguing matchup. Louisville is getting 7.5 yards per play, which allows its offense to step up, but SMU is allowing just 51.2% of passes to be completed against them.

The Mustangs' offense needs to do better in their first season in the Atlantic Coast Conference but has scored 108 points over the last two weeks against Florida State and TCU. It is difficult to imagine the Cardinals' defense slowing them down too much.

Sports Illustrated's SP+ has this game projected to see Louisville secure a close 30-24 win at home with a 64% chance of victory.

Louisville turned the ball over three times (two lost fumbles and one interception) last week. Both teams have been incredible on the defensive side of the ball and this game should be a close affair as a result.

SMU vs. Louisville betting tips

If you are looking at the spread, which is currently sitting with Louisville being favored at home by 6.5 points at the time of writing, SMU +6.5 is the play here. The SP+ model has this game being a six-point difference, right at the edge of what the model has projected for this game.

What time is the SMU vs. Louisville game on?

This game between the new Atlantic Coast Conference opponents is scheduled to take place at noon ET on Saturday. The game will be aired nationally on ESPN for people watching on linear television while also available on multiple streaming platforms, including ESPN+ and Hulu + Live Sports.

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