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49ers vs Seahawks prediction, picks and fantasy outlook feat. George Kittle

George Kittle's San Francisco 49ers are set to face off against DK Metcalf's Seattle Seahawks on Thursday Night Football. The NFC West battle has especially high stakes as the winner of the game will command first place in the division.

With so much at stake, stress for both fanbases is at an all-time high. Here's an in-depth look at the players, teams and what to expect.

49ers vs Seahawks prediction

George Kittle at New England Patriots v San Francisco 49ers - Source: Getty
George Kittle at New England Patriots v San Francisco 49ers - Source: Getty

Seattle is coming off a massive toe-stub after losing to the New York Giants. Many attributed the loss to overlooking the Giants in favor of the 49ers. The team's confidence has undoubtedly been tested after losing to Daniel Jones' under .500 unit.

That said, with the game taking place in Seattle, the 'Hawks will have home-field advantage. Expect a tightly contested, low-scoring game. The Seahawks should come out on top over George Kittle's 49ers in a defensive slugfest.

49ers vs Seahawks fantasy picks

Kenneth Walker III at Seahawks at Lions - Source: Getty
Kenneth Walker III at Seahawks at Lions - Source: Getty

Both teams have faced each other two times per season for decades. As such, both rosters and coaches are well-versed in how the other side plays. As a result, expect few plays to take the defenses off guard.

George Kittle, with his size and strength, is likely to be a player to watch for fantasy managers. However, he doesn't appear to be 100% healthy going into the contest. Brandon Aiyuk is also a player to keep an eye on after earning 147 yards last week.

For the Seahawks, Kenneth Walker III and DK Metcalf are the biggest players to look out for. The 49ers have given up decent running games to Kyren Williams and James Conner in the past three weeks, so expect a rushing surge. DK Metcalf also is one of the key pieces of the offense, so he is projected to earn plenty of looks from Geno Smith.

Where to watch 49ers vs Seahawks on cable

Brock Purdy at New England Patriots v San Francisco 49ers - Source: Getty
Brock Purdy at New England Patriots v San Francisco 49ers - Source: Getty

Unfortunately, the 49ers vs Seahawks game won't be available on cable anywhere in the country. As part of Amazon Prime's Thursday Night Football slate, the game will be available only to Prime subscribers. This is the case for every Thursday Night Football game except Week 1's regular-season kickoff.

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