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Best DFS Picks for Tennessee Titans vs. Indianapolis Colts - October 23 | 2022 NFL Football Season

The Tennessee Titans host the Indianapolis Colts in a match-up of AFC South rivals that know each other well. Head coach Mike Vrabel and the Tennessee Titans have righted the ship following a slow start to the season. The Indianapolis Colts are still searching for the proper balance on offense. The return of All-Pro running back Jonathan Taylor should help.

Today we look at the best DFS plays from this intriguing match-up.

Best quarterback picks

Cash and tournament games: Matt Ryan, QB, Indianapolis Colts (DraftKings $5.4K, FanDuel $7.3K)

Matt Ryan is worth a look in either Cash Games or Tournament Play. Ryan saw his passing volume skyrocket in the absence of Jonathan Taylor. We won't see the Colts' offense pass to that extreme this week against Tennessee, but the best way to attack the Titans is through the air. A game plan centered around Ryan this week would make sense.

It's advisable to stay clear of Ryan Tannehill. The Titans don't throw the ball enough and want their offense to run through Derrick Henry.

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Best running back picks

Cash Games: Jonathan Taylor, RB, Indianapolis Colts (DraftKings $8.1K, FanDuel $8.0K)

Under normal circumstances, Jonathan Taylor is priced as one of the top two options for the running back position. DFS players received a slight discount on Taylor this week since he has been out of the lineup the last two weeks. Taylor should see ownership between 10-12 percent, and savvy DFS players can take advantage.

Tournament: Derrick Henry, RB, Tennessee Titans (DraftKings $8.2K, FanDuel $9.2K)

The Indianapolis Colts defense has been tough against the run this season, and we see that respect played out in the initial ownership projections.

Henry is expensive, but initial estimates point to 5-7 percent ownership. Paying up for Henry is a way to gain leverage against the field this week, and provides correlation for those loading up on a Colts stack.

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Wide receivers and tight ends

Cash game: Michael Pittman Jr., WR, Indianapolis Colts (DraftKings $7.4, FanDuel $7.5)

Michael Pittman Jr. is one of the favorite plays at the WR position—in Cash and Tournament considerations. There are other attractive options in a similar price range, but Pittman Jr. at 3 percent ownership is inexcusable. DFS players should take advantage of a sleeping market on Pittman Jr. and get him in your lineups.

Tournament: Alec Pierce, WR, Indianapolis Colts (DraftKings $4.6, FanDuel $6.1)

The Colts' passing stack this week is good. The Titans' secondary will struggle to match up on the back end. We just saw Alec Pierce find the end zone last week, and as a cheap flier at 1 percent ownership, Pierce is a steal.

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