Buffalo Bills schedule 2025: Game-by-game win-loss record predictions for all 17 games
The Buffalo Bills, led by 2024 MVP Josh Allen, will be looking to finally achieve the top prize in the NFL next season after years of playoff failures.
The Bills had a strong 2024 regular season, finishing with a record of 13-4 and securing the No. 2 seed in the AFC. However, Buffalo fell short of a Super Bowl appearance once again, losing 32-29 to Patrick Mahomes' Kansas City Chiefs.
Using the Sportskeeda Playoff Predictor, let's take a look at the Bills' 2025 schedule and project their final record.
Buffalo Bills 2025 Schedule
Week 1 (September 7): vs. Baltimore Ravens at home, 8:20 PM ET
Week 2 (September 14): at New York Jets, 1 PM ET
Week 3 (September 18): vs. Miami Dolphins at home, 8:15 PM ET
Week 4 (September 28): vs. New Orleans Saints at home, 1:00 PM ET
Week 5 (October 5): vs. New England Patriots at home, 8:20 PM ET
Week 6 (October 13): at Atlanta Falcons, 7:15 PM ET
Week 7: BYE
Week 8 (October 26): at Carolina Panthers, 1:00 PM ET
Week 9 (November 2): vs. Kansas City Chiefs at home, 4:25 PM ET
Week 10 (November 9): at Miami Dolphins, 1:00 PM ET
Week 11 (November 16): vs. Tampa Bay Buccaneers at home, 1:00 PM ET
Week 12 (November 20): at Houston Texans, 8:15 PM ET
Week 13 (November 30): at Pittsburgh Steelers, 4:25 PM ET
Week 14 (December 7): vs. Cincinnati Bengals at home, 4:25 PM ET
Week 15 (December 14): at New England Patriots, 1:00 PM ET
Week 16 (December 21): at Cleveland Browns, 1:00 PM ET
Week 17 (December 28): vs. Philadelphia Eagles at home, 4:25 PM ET
Week 18 (TBD): vs. New York Jets at home, time TBD
Buffalo Bills 2025: Game-by-Game Prediction
Week 1: Bills vs. Ravens
Prediction: 15-13
Week 2: Bills at Jets
Prediction: 25-21
Week 3: Bills vs. Dolphins
Prediction: 18-15
Week 4: Bills vs. Saints
Prediction: 17-15
Week 5: Bills vs. Patriots
Prediction: 33-18
Week 6: Bills at Falcons
Prediction: 38-25
Week 7: BYE
Week 8: Bills at Panthers
Prediction: 16-15
Week 9: Bills vs. Chiefs
Prediction: 29-24
Week 10: Bills at Dolphins
Prediction: 24-22
Week 11: Bills vs. Buccaneers
Prediction: 14-15
Week 12: Bills at Texans
Prediction: 14-15
Week 13: Bills at Steelers
Prediction: 21-19
Week 14: Bills vs. Bengals
Prediction: 16-15
Week 15: Bills at Patriots
Prediction: 32-29
Week 16: Bills at Browns
Prediction: 24-27
Week 17: Bills vs. Eagles
Prediction: 24-19
Week 18: Bills vs. Jets
Prediction: 30-16
Buffalo Bills' predicted 2025 regular-season record
Sportskeeda's Playoff Predictor projected that the Bills would finish the regular season with a record of 14-3 and secure first place in the AFC East division.
According to this prediction, the Bills would also earn the No. 1 seed in the AFC and receive a bye in the first round of the playoffs.