Tennessee Titans vs. Buffalo Bills: Odds, Lines, Picks, and Predictions September 19, 2022 | 2022 NFL Regular Season
The Tennessee Titans head north to play the Buffalo Bills for their second game of the season. After losing to the New York Giants in Week 1 due to a missed field goal, the Titans now face a tough challenge with the Super Bowl favorite Bills.
Buffalo had nine days off after opening up the season on Thursday Night Football in Los Angeles. They handled the current Super Bowl Champions with ease, 31 - 10. This game could have been a symbolic passing of the Lombardi baton.
The Orchard Park Central School District and the Frontier Central School District will have a half-day Monday because of the Bills and Titans game. Parents, what are your thoughts? https://t.co/taJO0eEQ5J
"...Frontier Central School District will have a half-day Monday because of the Bills and Titans game. - @WGRZ
There were high hopes for the Titans after winning the AFC South last year, but after a terrible loss in Week 1 and an impeeding L in Week 2, their season isn't off to a dazzling start.
"Welcome to Highmark Stadium home of the @buffalobills" - @coldfrontreport_billsnews
Tennessee Titans vs. Buffalo Bills match details
Fixture: Tennessee Titans @ Buffalo Bills
Date & Time: Monday, September 19, 7:15 PM ET.
Venue: Highmark Stadium, Orchard Park, NY
Tennessee Titans vs. Buffalo Bills betting odds
Tennessee Titans vs. Buffalo Bills best picks
With the likely fortune of the Bills spending plenty of time in the endzone, bettors can almost blindly pick a player to score a touchdown. However, a play that not many will make that will have a fantastic payout is Dawson Knox scoring an anytime touchdown. Josh Allen should get the tight ends involved in the endzone, and with the given odds, its a great play.
Dawson Knox Anytime Touchdown (+145)
Buffalo are extremely excited to have their home opener be against a team like the Titans. They want to run up the score and give the hometown fans plenty to cheer about. While Tennessee can't be counted on to carry their weight in the game total over, the Bills team total is a lock in this one.
Buffalo Over 28.5 Points (-110)
Tennessee Titans vs. Buffalo Bills prediction
As much as I like a good upset, the Titans have no hope in this one. They came out flat in Week 1, and the Bills played like champions in their first game. There is only so much information available for bettors to go off, but even with all the experience Ryan Tannehill has against Buffalo, it's going to be ugly.
Buffalo -9.5 (-115)