Week 17 MNF Lions vs. 49ers prediction and fantasy picks feat. Jahmyr Gibbs, George Kittle and more

Week 17 of the 2024 NFL season concludes with a Monday Night Football matchup between the Detroit Lions and San Francisco 49ers. While this game will not impact the outlook of the NFL Playoffs this year, both teams are expected to play all of their starters. This makes for an intriguing game, including for those still participating in fantasy football this week.

Detroit Lions vs San Francisco 49ers prediction

Sportskeeda's NFL Playoff Predictor

The Detroit Lions have been one of the best overall teams in the NFL this season. They have held the first seed in the NFC for the upcoming playoffs for most of the year, but they will enter Week 17 needing one more victory in order to officially earn it.

A win against the San Francisco 49ers this week won't be enough to get the job done. Their Week 18 matchup against the Minnesota Vikings is for the ultimate stakes, with the winner of that game getting the top seed, first-round bye and home-field advantage in the playoffs.

While this game is essentially meaningless for the Lions, as well as for the 49ers, who have already been eliminated from playoff contention, all starters are expected to play this week. This doesn't come as a surprise for the 49ers, but it's an interesting decision by the Lions to not take the opportunity to rest their starters.

Nevertheless, coach Dan Campbell stated earlier this week that regardless of their situation, they plan to play all of their starters and approach the game looking for a victory as they would in any other week. This strategy is enough for Sportskeeda's NFL Playoff Predictor to pick the Lions as the winning side over the 49ers in Week 17 on Monday Night Football.

Prediction: Lions 18 - 49ers 15

Week 17 Detroit Lions vs San Francisco 49ers fantasy picks

Sportskeeda's Who Should I Start tool

Jahmyr Gibbs has been one of the best fantasy football running backs this year. He currently ranks as the overall RB4 and has finished among the weekly top 12 in five of his past six games.

He is the clear workhorse now that David Montgomery is out with an injury and Sportskeeda's Who Should I Start tool picks him as the top running back from this matchup.

He is joined by George Kittle, who enters Week 17 currently ranked as the overall TE2 this season. He has finished among the top 12 players in his position in 12 of his 13 games this year. He can be trusted again in Week 17 fantasy lineups this week as an elite option.

Start 'Em

• Brock Purdy
• Jahmyr Gibbs
• Isaac Guerendo
• Amon-Ra St. Brown
• Deebo Samuel
• George Kittle
• Sam LaPorta

Sit 'Em

• Jared Goff
• Craig Reynolds
• Patrick Taylor
• Jameson Williams
• Jauan Jennings

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