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49ers vs. Cardinals: Who Will Win? Betting Prediction, Odds, Lines, and Picks for NFL Games Today - November 21 | 2022 NFL Football Season

The San Francisco 49ers (5-4), second in the NFC West, will face the Arizona Cardinals (4-6), who are in third place in the NFC West. The teams are squaring off on Monday Night Football to wrap up Week 11 in Mexico City.

San Francisco is currently on a two-game winning streak after a 22-16 home win last week against the Los Angeles Chargers. Arizona is coming off a 27-17 road win against the Los Angeles Rams last week as well.

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San Francisco 49ers vs. Arizona Cardinals: Betting Odds

TeamMoneylineSpreadOver/Under
San Francisco 49ers-435-10 (-110)O 43 (-110)
Arizona Cardinals +350+10 (-110)U 43 (-110)

Arizona Cardinals vs. San Francisco 49ers Best Picks:

Christian McCaffrey Anytime TD (-150)

In his three games since being traded from the Carolina Panthers to the San Francisco 49ers, Christian McCaffrey has been able to find that next gear and has scored three touchdowns: two rushing and one receiving.

The Arizona Cardinals are currently tied for the fourth-most touchdowns with the Cleveland Browns this season (30). Their defense is expected to give up some points as well.

Colt McCoy Over 226.5 Passing Yards (-115)

Colt McCoy is arguably the best backup quarterback in the entire National Football League. He is making his second consecutive start for the Cardinals here as Kyler Murray continues to recover from a hamstring injury. Last week against the Los Angeles Rams, McCoy finished going 26-of-37 for 238 yards with a touchdown and zero interceptions.

The Cardinals have solid wide receiver options with DeAndre Hopkins and Rondale Moore. Tight end Zach Ertz has the ability to get open and do well throughout the game against a decent, but not great, secondary for San Francisco.

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Arizona Cardinals vs. San Francisco 49ers Prediction

The Arizona Cardinals will be without their starting quarterback Kyler Murray for the second consecutive game. It is a huge blow to their chances in this game. Despite that, they have arguably the best backup quarterback, Colt McCoy.

The 49ers are averaging 25.3 points in their last three games while the Cardinals are scoring 24.7 points in that same stretch. San Francisco should win the game on the moneyline, but this spread is a little too much for our liking.

Pick: Arizona Cardinals +10 (-110)

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