Best DFS Picks for Monday Night Football-San Francisco 49ers vs. Arizona Cardinals- November 21 | 2022 NFL Regular Season
The San Francisco 49ers continue their playoff push as they head to the desert to face AFC West rivals the Arizona Cardinals. Who will be victorious on Monday Night Football?
Today we look at the best DFS plays from this intriguing match-up.
Best quarterback picks San Francisco 49ers vs. Arizona Cardinals
Cash Games: Jimmy Garoppolo, QB, San Francisco 49ers (DraftKings $14.4K, FanDuel $14.5K)
Jimmy Garoppolo has some of the best weapons in the NFL at his disposal. Garoppolo isn't the best name in the DFS pool, but has a substantial floor in a terrific match-up.
Tournaments: Colt McCoy, QB, Arizona Cardinals (Draftkings $14.1K, FanDuel $14K)
The latest reports out of Arizona are that Colt McCoy will be the starter for Arizona. McCoy doesn't run anywhere near as well as Kyler Murray, but is a highly-effective veteran QB.
$1,000 No Sweat First Bet in FanDuel
Best running back picks
Cash Games: Christian McCaffrey, RB, San Francisco 49ers (DraftKings $17.1K, FanDuel $16.5K)
Ever since San Francisco traded for Christian McCaffrey, they have made it a point of emphasis to get C-Mac involved as a runner and receiver. McCaffrey even threw a TD pass in his second game as a 49er. San Francisco knows what they have in Christian McCaffrey and will utilize him to the fullest extent.
Tournament: James Conner, RB, Arizona Cardinals (DraftKings $12.9K, FanDuel $11K)
Everyone is going to put Christian McCaffrey in their DFS lineup. Few players will rush to select James Conner. Against an offensive line that has a history of being bullied, James Conner could be used in the passing game more often on Monday night.
Wide receivers and tight ends
Cash game: DeAndre Hopkins, WR, Arizona Cardinals (DraftKings $15.6K, FanDuel $16K)
DeAndre Hopkins has been the focal point of the Cardinals' offense since returning from his six-game suspension. The Cardinals' will struggle to run the ball against San Francisco's front seven. Expect Arizona to open up the offense and get DeAndre Hopkins involved early and often.
Tournament: George Kittle, TE, San Francisco 49ers (DraftKings $10.5K, FanDuel $10K)
Playing George Kittle this week in DFS is a calculated risk. Admittedly, George Kittle hasn't been great for fantasy. With so many weapons, Jimmy Garopolo does not need to force-feed the dynamic TE. The 49ers also run the football as much and as effectively as any team in the NFL. The Cardinals are the worst team in the NFL against the TE position. If there was a time for George Kittle to break out of his funk, now would be the time.
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