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Best NFL Parlay Bets for Today: 49ers vs. Cardinals (+592)- Week 11 - November 21 | 2022 NFL Football Season

We have an NFC West showdown this week with the San Francisco 49ers and the Arizona Cardinals in a Week 11 matchup.

San Francisco is currently second in the division with a 5-4 record and are on a two-game winning streak. They are coming off a 22-16 road victory over the Los Angeles Chargers last Sunday.

The Cardinals are third in the division with a 4-6 record, coming off a 27-17 road win against the Los Angeles Rams last Sunday as well.

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San Francisco 49ers vs. Arizona Cardinals Match Details

Fixture: San Francisco 49ers @ Arizona Cardinals

Date & Time: Monday, November 21, 8:15 p.m. EDT

Venue: Estadio Azteca, Mexico City, Mexico


San Francisco 49ers vs. Arizona Cardinals Parlay Leg #1 - Arizona +10 (-110)

Let's start with the spread in this game as our first leg of the parlay! The Cardinals are going to have Colt McCoy get the start, which makes the game more interesting as the spread is now double-digit on a neutral site. These offenses have been neck and neck with one another as San Francisco has scored 22 points per game while Arizona is averaging 23 points per game so far.

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San Francisco 49ers vs. Arizona Cardinals Parlay Leg #2 - Jimmy Garoppolo Under 1.5 Passing Touchdowns (+105)

This comes with the understanding that in four of his last five games, Garoppolo has thrown two touchdown passes. However, San Francisco would rather take the ball out of his hands than have Garoppolo throw the ball too much. In his last two games, he is averaging 26.5 passing attempts. He is not dropping back too much as well.

Keep in mind that San Francisco has been running the ball effectively as they now have two incredible running backs in Christian McCaffrey and a hybrid running back in DeeBo Samuel. Expect "San Fran" to run the football in the red zone here and go with the under.

San Francisco 49ers vs. Arizona Cardinals Parlay Leg #3 - Jimmy Garoppolo Over 1.5 Rushing Yards (-130)

Jimmy Garoppolo has hit at least two yards in each of his last four games and is averaging 2.8 rushing attempts in that span as well. Running for a couple of yards seems like a lock.

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