Best Parlay (+469) for Arizona Cardinals vs Seattle Seahawks - Week 6 - October 16 | 2022 NFL Football Season

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On Sunday, the Arizona Cardinals (2-3) will travel to the Evergreen State to face off against the Seattle Seahawks (2-3). The two NFC West clubs will joust for a potential share of first place in a crowded division.

Arizona most recently dropped a home game against the Philadelphia Eagles, where they continued a remarkable streak of remaining scoreless in the first quarter for five games.

The Cardinals showed signs of life in the second half but fell to the NFL's lone unbeaten team. Meanwhile, Seattle scored 30+ points for the second week in a row but got undressed by New Orleans TE Taysom Hill in a 39-32 defeat.

The NFL's Swiss Army Knife did what he pleased, scoring four total touchdowns on nine rush attempts and a singular pass. Below, we'll go through the best parlay to make for Sunday's contest.

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NFL Parlay Leg #1: Over 50.5 Points (-106)

One of the feel-good stories of the 2022 NFL season is the play of former second-round pick Geno Smith.

Smith, a superstar at West Virginia University, was, in the words of Stephen A. Smith, a 'bonafide scrub' during his years with the New York Jets. Nevertheless, the prospect turned journeyman settled in Seattle as a backup for Russell Wilson before being handled the keys to the offense this past offseason.

The 32-year-old is finally living up to his potential, leading the NFL in completion percentage (76%) while throwing nine touchdowns against two interceptions. The Jets' scout, who pounded the table to use a top-40 pick on Geno, must be at the local watering hole saying, "I told you so."

The Seahawks' offense ranks in the top ten in the NFL with total yards and points. That should make for a dream matchup against a Cardinals secondary that ranks 21st in the NFL in passing yards allowed.

Meanwhile, the Seattle defense may be the worst unit in football, ranking in the bottom three in the NFL in total yards, rushing yards, and points allowed. The Cardinals should finally be able to put it all together on offense, led by franchise QB Kyler Murray.

NFL Parlay Leg #2: Kyler Murray Any Time Touchdown Scorer (+135)

Speaking of Kyler Murray, the QB has taken a step back this season after having MVP hype surrounding him last year.

The Pro-Bowler may not be replicating his 2021 start to the season but is in a position for a big statement game on Sunday. Murray, who has already scampered for two rushing touchdowns this season, will represent a colossal scheme issue for the 32nd-ranked rush defense in the NFL.

New Orleans Saints QB/TE Taysom Hill just went for 112 rushing yards a three tuddies on only nine rushes, so it isn't far-fetched to think the even more light-footed Murray can find the endzone with his legs. Murray should use his legs to cash the any time TD leg of the parlay.

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NFL Parlay Leg #3: Eno Benjamin 40+ Rushing Yards (-420)

The theme here is to bet against the Seahawks' rush defense. Nobody should mistake Eno Benjamin for a household name, but the Arizona State product could have little competition for touches on Sunday.

Lead back James Conner, and free agent pickup Darrel Williams have both been ruled out for the game against Seattle, leaving Benjamin as the only back on the roster with NFL experience. Expect Benjamin to get at least 15 carries in his first NFL start. He might return to a change-of-pace role if he can't get three yards a carry against the Seattle front seven.

NFL Parlay Leg #4: Tyler Locker 50+ Receiving Yards (-275)

Someone must be the beneficiary of Geno Smith spinning the rock on Sunday. WR Tyler Lockett, who operated out of the slot and out by the numbers, has a 26.1% target share for the year.

He should be peppered early and often against a Cardinals secondary that just got cooked by Eagles WR Devonta Smith. WRs with a similar skill set to Lockett, like Vegas WR Hunter Renfrow and Kansas City WR JuJu Smith-Schuster, both eclipsed the 50-yard threshold in their matchups with Arizona. Lock Lockett, pun intended, into the parlay.