UFC Fight Night: Dern vs. Rodriguez is a mixed martial arts event produced by the Ultimate Fighting Championship that took place on October 9, 2021 at the UFC APEX, Las Vegas United States.
Main Card
| Weight Class | Fight | Method | Round | Result |
| Women Strawweight | Mackenzie Dern vs. Marina Rodriguez | Decision | R5 (05:00) | Marina Rodriguez def. Mackenzie Dern |
| Welterweight | Randy Brown vs. Jared Gooden | Decision | R3 (05:00) | Randy Brown def. Jared Gooden |
| Flyweight | Tim Elliott vs. Matheus Nicolau | Decision | R3 (05:00) | Matheus Nicolau def. Tim Elliott |
| Women Flyweight | Sabina Mazo vs. Mariya Agapova | Submission | R3 (00:53) | Mariya Agapova def. Sabina Mazo |
| Middleweight | Chris Gutierrez vs. Felipe Colares | Decision | R3 (05:00) | Chris Gutierrez def. Felipe Colares |
Preliminary Card
| Weight Class | Fight | Method | Round | Result |
| Heavyweight | Alexandr Romanov vs. Jared Vanderaa | KO/TKO | R2 (04:43) | Alexandr Romanov def. Jared Vanderaa |
| Featherweight | Charles Rosa vs. Damon Jackson | Decision | R3 (05:00) | Damon Jackson def. Charles Rosa |
| Women Strawweight | Lupita Godinez vs. Silvana Gomez Juarez | Submission | R1 (04:14) | Lupita Godinez def. Silvana Gomez Juarez |
| Lightweight | Steve Garcia vs. Charlie Ontiveros | KO/TKO | R2 (01:51) | Steve Garcia def. Charlie Ontiveros |
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